منابع مشابه
Mitochondria in aging cell differentiation
key organelles of eukaryotic cells that are responsible for essential metabolic processes, generation of energy, cellular redox state and many other processes, are deeply involved in cellular homeostasis and influence overall cell/organism physiology. Defects in mitochondria can lead to a number of different disorders in mammals [1]. Changes in the functional state of mitochondria can induce ce...
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The free radical theory of aging postulates that the production of intracellular reactive oxygen species is the major determinant of life span. Numerous cell culture, invertebrate, and mammalian models exist that lend support to this half-century-old hypothesis. Here we review the evidence that both supports and conflicts with the free radical theory and examine the growing link between mitocho...
متن کاملThe Aging Mitochondria
Mitochondrial dysfunction is a central event in many pathologies and contributes as well to age-related processes. However, distinguishing between primary mitochondrial dysfunction driving aging and a secondary mitochondrial impairment resulting from other cell alterations remains challenging. Indeed, even though mitochondria undeniably play a crucial role in aging pathways at the cellular and ...
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1Division of Biology of Aging, Department of Aging and Geriatric Research, College of Medicine, Institute on Aging, University of Florida, Gainesville, FL 32611, USA 2Department of Experimental Medicine, Faculty of Medicine, University of Lleida-IRBLleida, 25008 Lleida, Spain 3Mitochondrial Gerontology and Age-Related Diseases Group, Institute of Biomedical Technology and Tampere University Hos...
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ژورنال
عنوان ژورنال: Aging
سال: 2016
ISSN: 1945-4589
DOI: 10.18632/aging.100993